Scleroderma pathophysiology

Pathophysiology of scleroderma: an update - ScienceDirec

  1. One of the most interesting phenomena in the pathophysiology of scleroderma is the persistence of the fibrogenic phenotype. In situ as well as in vitro fibroblasts with different synthesizing capacities for extracellular matrix proteins could be found
  2. Scleroderma is an autoimmune disorder, characterized by morphological changes in skin followed by visceral organs. The pathogenesis of scleroderma involves immune imbalance and generation of auto antibodies. The major causes of scleroderma include multitude of factors such as immune imbalance, oxidative stress, genetics and environment factors
  3. The pathogenesis of systemic sclerosis is complex. [ 6, 7, 8, 9, 10, 11, 12, 13] Increasing evidence suggests interaction between environmental and genetic factors, with a regulatory epigenetic..
  4. Scleroderma results from an overproduction and accumulation of collagen in body tissues. Collagen is a fibrous type of protein that makes up your body's connective tissues, including your skin. Doctors don't know exactly what causes the abnormal collagen production to begin, but the body's immune system appears to play a role
  5. Scleroderma is a chronic, although rare, autoimmune disease in which normal tissue is replaced with dense, thick fibrous tissue. Normally, the immune system helps defend the body against disease and infection. In patients with scleroderma, the immune system triggers other cells to produce too much collagen (a protein)

Scleroderma is best thought of as a disease with two components: genetic susceptibility and a trigger event, for example, exposure to silica dust. A number of researchers have investigated the possible link between scleroderma and silicone breast implants (e.g., Lipworth et al. 2011). To date, all of these studies have shown no causal link INTRODUCTION The pathogenesis of systemic sclerosis (SSc; scleroderma) is complex and remains incompletely understood. Immune activation, vascular damage, and excessive synthesis of extracellular matrix with deposition of increased amounts of structurally normal collagen are all known to be important in the development of this illness [ 1,2 ] NOT an infection. We also know that a person develops scleroderma when the body makes too much collagen. This excess collagen is what causes the skin to thicken and harden. It can also cause hardening and thickening in the tendons, joints, and parts of the internal organs. Why this happens is still a bit of a mystery Pathophysiology It is characterised by increased synthesis of collagen (leading to the sclerosis), damage to small blood vessels, activation of T lymphocytes, and production of altered connective tissue. Its proposed pathogenesis is the following: It begins with an inciting event at the level of the vasculature, probably the endothelium

Scleroderma: An insight into causes, pathogenesis and

Scleredema is an uncommon, but likely underrecognized, fibromucinous connective-tissue disease. It is characterized clinically by woody induration and hardening of the skin that results from excessive mucin deposition between thickened collagen bundles in the skin's dermis. The term scleredema is a misnomer because neither sclerosis nor edema. Systemic sclerosis (SS) is an autoimmune disorder. This means it's a condition in which the immune system attacks the body. Healthy tissue is destroyed because the immune system mistakenly thinks.. The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration... Anyone can have scleroderma. No one knows what causes the disease, although there are many clues including genetic predisposition. There is no cure and no drugs that halt the progression of the disease or reverse it. The fibrosis at the center of scleroderma makes it prototypic for all other fibrotic diseases

What is the pathophysiology of scleroderma

Scleroderma is a long-lasting disease that affects your skin, connective tissue, and internal organs. It happens when your immune system causes your body to make too much of the protein collagen,.. Scleroderma causes hardening and tightening of the skin but may also affect other body parts. Scleroderma, which means hard skin, is a rare disease that affects the skin and connective tissue (fibers that provide structure and support to the body). There are two types of scleroderma - localized and systemic (sometimes called systemic.

Investigation of pathophysiology of scleroderma is effected by monitoring the serum levels for soluble mediators, by cell culture studies of affected and non-affected fibroblasts and EC, by studying environmentally induced forms of scleroderma and by studies using animal models Scleroderma is an autoimmune connective tissue and rheumatic disease that causes inflammation in the skin and other areas of the body. This inflammation leads to patches of tight, hard skin. Scleroderma involves many systems in your body. A connective tissue disease is one that affects tissues such as skin, tendons, and cartilage

In scleroderma, the immune system damages healthy tissue like collagen and replaces it with scar tissue, causing thickening and tightening of the skin as well as damage to other organs and systems Pathophysiology. Figure 1. Multiple sclerosis- demyelination (Taylor, 2017) In MS, the immune system triggers a T and B cell response to myelin self-antigens, which starts the beginning of the early inflammatory demyelination process. The autoimmune response triggers peripheral activation of CD4+ T-cells and CD8+ T-cells, which cross the blood. Scleroderma is an autoimmune condition of the connective tissue characterized by skin thickening, spontaneous scarring, blood vessel disease, and varying degrees of inflammation, associated with an overactive immune system. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system Scleroderma renal crisis (SRC) is an infrequent but serious complication of systemic sclerosis (SSc). It is associated with increased vascular permeability, activation of coagulation cascade, and renin secretion, which may lead to the acute renal failure typically associated with accelerated hypertension. The histologic picture of SRC is that of a thrombotic microangiopathy process with. From Wikipedia, the free encyclopedia Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries

This video contains a detailed and simplified explanation of systemic sclerosis and scleroderma. We discuss the pathophysiology, presentation, features, inve.. The cause of multiple sclerosis is unknown. It's considered an autoimmune disease in which the body's immune system attacks its own tissues. In the case of MS, this immune system malfunction destroys the fatty substance that coats and protects nerve fibers in the brain and spinal cord (myelin) Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The word scleroderma comes from the Greek word sclero, meaning hard, and the Latin word derma, meaning skin. Hardening of the skin is one of the most visible manifestations of the disease

Scleroderma causes. The exact cause or causes of scleroderma are still unknown. It is known that scleroderma results from an overproduction and accumulation of collagen in your body tissues. Collagen is a fibrous type of protein that makes up your body's connective tissues, including your skin Systemic sclerosis is an autoimmune condition. This means that the immune system, which protects you from illness and infection, gets confused and attacks the body's own cells. The word systemic means a condition that can affect the whole body. Sclerosis means the hardening of a structure. Systemic sclerosis affects more women than men Objectives . To review the pathophysiological background of systemic sclerosis in relation to the main components involved: microvascular system, immunological system and fibroblasts of the connective tissue.. Background . Although many particular aspects of the pathophysiology of systemic sclerosis have been investigated in recent years, the complexity of the pathogenesis and the important. Systemic scleroderma is an autoimmune disorder that affects the skin and internal organs. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. The word scleroderma means hard skin in Greek, and the condition is characterized by the buildup of scar tissue (fibrosis) in the skin and other.

Scleroderma In Saginaw, MI. Scleroderma is an autoimmune condition characterized by hardening or scarring of the skin and connective tissues. Scleroderma is generally more prevalent in women than men and typically affects individuals aged between 30 and 50. Scleroderma occurs due to an overproduction of collagen, the most abundant protein in. tendonitis or other causes. However, Scleroderma patients get Carpal Tunnel Syndrome due to the swelling from leaking blood vessels and buildup of scar tissue. This narrowing causes pain and numbness. Other nerves can get trapped as well. For example, the ulner nerve in your elbow can get trapped due to the tightness of the skin

Definition / general. Characterized by fibrosis, inflammation, increased collagen and vasculitis. Can be part of CREST syndrome ( C alcinosis, R aynaud phenomenon, E sophageal involvement, S clerodactyly, T elangiectasia) Involves esophagus in 75%+ patients, usually distal 2/3, with aperistalsis and reduced tone of lower esophageal sphincter Systemic sclerosis is a rare, chronic autoimmune rheumatic disorder characterized by degenerative changes and scarring in the skin, joints, and internal organs and by blood vessel abnormalities. The cause of systemic sclerosis is unknown. Swelling of the fingers, intermittent coolness and blue discoloration of the fingers, joints freezing in. Gastrointestinal manifestations of scleroderma can occur in up to 90% of patients with scleroderma 2 with the most common site of gastrointestinal involvement being the esophagus.After skin changes and Raynaud phenomenon, gastrointestinal changes are the third most common manifestation of scleroderma.. As the clinical presentation, radiographic appearances and differential diagnosis vary with.

Scleroderma - Symptoms and causes - Mayo Clini

Pathophysiology of SSc-related Raynaud's phenomenon. In SSc, secondary RP is the initial or heralding symptom in over 90% of patients, and it may also present the overture in the pathophysiology of SSc, setting the tone for the processes leading to sclerosis [ 1]. Also, vascular changes in the skin may at least partially reflect vascular. The following is an excerpt from chapter 23 of Systemic Sclerosis, 2nd Edition written by Dr. Laura Hummers and Dr. Fred Wigley. Download the full chapter at the bottom of this page.. Because no two cases of Scleroderma are alike, identifying your disease subtype, stage, and involved organs is very important in determining the best course of action for treatment Symptoms of scleroderma include. Calcium deposits in connective tissues. Raynaud's phenomenon, a narrowing of blood vessels in the hands or feet. Swelling of the esophagus, the tube between your throat and stomach. Thick, tight skin on your fingers. Red spots on your hands and face. No one knows what causes scleroderma. It is more common in women Scleroderma causes your body to produce too much collagen . Collagen is a protein that makes up connective tissues, such as the skin. When you have too much collagen, your skin can stretch, thicken, and harden. It also can cause damage to internal organs, such as the heart , lungs , and kidneys

Scleroderma is a collagen vascular disease characterized by the hardening and thickening of the skin. Scleroderma relates to rheumatic diseases as well as connective tissue diseases. Conditions related to rheumatic diseases include inflammation or pain in the joints, muscles or fibrous tissues. Connective tissue diseases affect the skin. What causes systemic sclerosis? Systemic sclerosis is an autoimmune condition characterised by inflammation, fibrosis and vasculopathy. The precise underlying mechanisms are complex and remain largely unknown. Genetic susceptibility plus a triggering event result in a cascade of innate and adaptive immunoinflammatory responses. Genetic.

Scleroderma is a chronic autoimmune disease characterized by patches of scar-like thick skin. This rare connective tissue disorder is caused by the buildup of a protein called collagen, the main component of scar tissue. Scleroderma, also known as systemic sclerosis, appears to develop spontaneously, and its underlying causes are largely unknown an autoimmune skin disease characterized by progressive hardening and induration of the skin and/or other structures such as the subcutaneous tissues, muscles, and internal organs. triad. autoimmunity. noninflammatory vasculopathy. collagen deposition with fibrosis. classification. localized scleroderma Systemic sclerosis (scleroderma, SSc) is a chronic autoimmune disease characterized by proliferative vascular lesions with resultant fibrosis of skin and multiple organs, including the gastrointestinal (GI) tract. Its aetiology is unknown, occurring most frequently in females, aged 35-65 years Systemic sclerosis (systemic scleroderma) is a chronic condition that occurs in two forms:. Diffuse cutaneous systemic sclerosis—the diffuse subset is seen in 10% of systemic scleroderma, often progressing quickly, and is potentially fatal.It can affect large areas of skin, causing thickening and hardening of the skin (sclerosis), abnormal changes with the arteries, joint problems, and. Scleroderma is a poorly understood illness that causes widespread hardening of the skin, especially on the hands and face. It also can damage the lungs, heart, kidneys, digestive tract, muscles and joints

Scleroderma: Symptoms, Causes, Diagnosis & Treatment

Limited cutaneous systemic sclerosis is the least severe type of systemic scleroderma. It affects the skin on the hands, feet, face, and lower arms and legs. There may be problems with the blood. Increased collagen deposition in tissues is a characteristic feature of systemic sclerosis. Increased collagen production or disturbances in its degradation can cause excessive collagen deposition. Causes . Systemic sclerosis is an autoimmune disease. Genetics and environmental factors likely play a role in triggering the disease, but much about the disease is unknown. Although researchers are not sure exactly what causes systemic sclerosis, some parts of the immune system appear to be overactivated in people who have the condition. The. The connective tissue of people with scleroderma has too much collagen, which causes it to become hard and tight. Scleroderma literally means 'hard skin'. Scleroderma is a chronic condition that results from a malfunctioning immune system. Your immune system is designed to identify foreign bodies (e.g. bacteria and viruses) and attack them.

Juvenile Scleroderma Types, Causes, Symptoms, Diagnosis

Scleroderma is a poorly understood illness that causes widespread hardening of the skin, especially on the hands and face. It also can damage the lungs, heart, kidneys, digestive tract, muscles and joints. It is a long-lasting (chronic) autoimmune disorder, an illness in which the body's immune defenses mistakenly attack the body's own cells. Scleroderma is an autoimmune disorder that can lead to a tightening or hardening of the skin and other soft, connective tissues. It is a chronic condition in which the immune system mistakenly attacks and damages your own body. This manifests as an overproduction of collagen, a protein that is a building block of connective tissues What Causes Scleroderma? Scleroderma is known to occur when there is too much production of collagen in the body and its accumulation takes place. Body's connective tissues are made by collagen, which is a form of protein. It is believed that the immune system in the body plays a possible role in abnormal collagen production Causes of scleroderma Normally, the body's immune system fights off any germs that infect the body. It responds like this to anything in the body it doesn't recognise, and settles down when the infection has been cleared. It's thought scleroderma occurs because part of the immune system has become overactive and out of control

Figure 1 from The pathogenesis of systemic sclerosis

Telangiectasias occur in patients who have both types of scleroderma: Limited scleroderma - also called CREST syndrome, which stands for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerosis and Telangiectasia. This primarily affects the skin of the face, hands and feet (with possible involvement of other organs) Causes of Scleroderma. Anyone can get scleroderma, though it impacts more women than men. It's unknown exactly what causes scleroderma, though it results from the immune system attacking your own body, causing an overproduction and accumulation of collagen in body tissues, says Dr. McMahan. Genetic and environmental factors likely play a part. The term scleroderma is taken from the Greek words skleros and derma. It simply means hard skin. Scleroderma is a rare group of autoimmune diseases, and they cause the skin or connective tissues to thicken and harden—it's also known as skin fibrosis.. According to the Scleroderma Foundation, scleroderma affects approximately 300,000 Americans

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that involves demyelination and axonal degeneration. Although substantial progress has been made in drug. Scleroderma involving the lungs is associated with a greater degree of skin scarring, or fibrosis, according to a new research model that seeks to predict a person's risk of organ-specific complications involved in that disorder.. The study, Correlation Between Skin and Affected Organs in 52 Sclerodermic Patients Followed in a Diseases Management Team: Development of a Risk Prediction. Calcinosis is a common complication of systemic sclerosis with no known effective pharmacologic therapy. We reviewed the literature regarding systemic sclerosis-related calcinosis as well as other disorders of biomineralization in order to identify targets of future study for calcinosis. Patients with systemic sclerosis-related calcinosis demonstrate systemic abnormalities in mineralization. Pediatric multiple sclerosis (pediatric MS) is MS that starts in the young. Symptoms such as muscle weakness and vision problems come and go, and the cause is not known. Fingolimod is a drug treatment Scleroderma means 'hard skin'. The most common symptom is a thickening and hardening of the skin, particularly of the hands and face. Connective tissue holds together and supports our joints, muscles, internal organs and skin. The connective tissue of people with scleroderma has too much collagen, causing it to harden and tighten

Subchondral sclerosis is a thickening of bone seen in joints affected by osteoarthritis. Get the facts. This raises the question of whether subchondral sclerosis actually causes, in part, the. MS causes the immune system to attack the myelin, which is the insulation protecting the nerves. The nerves themselves can also be damaged. When myelin or the nerves become damaged, nerves cannot properly pass along their signals. The damaging process forms scar tissue called sclerosis, which gives the disease its name of multiple sclerosis Multiple Sclerosis (MS) is a neurological disease that affects the brain and spinal cord. This occurs because of damage to the outer layer of nerve called the myelin sheath. An autoimmune response occurs, and the body attacks part of the nerve called the myelin sheath

Causes of Scleroderma - Scleroderma Education Projec

Multiple sclerosis is a complex and heterogeneous autoimmune disease. It affects the central nervous system, which includes the brain and spinal cord. Some scientists call it the disease with a thousand faces.Here, we'll look at some of the early signs of multiple sclerosis Localized scleroderma is characterized by thickening of the skin from excessive collagen deposits. Collagen is a protein normally present in our skin that provides structural support. However, when too much collagen is made, the skin becomes stiff and hard. Localized types of scleroderma are those limited to the skin and related tissues and, in some cases, the muscle below Another symptom of scleroderma is the presence of white, chalky lumps caused by increased calcium in the body. This is not due to overconsumption of calcium. Raynaud's disease, which causes calcium deposits in the lungs and on skin, causes this symptom. Other Symptoms. Other symptoms of scleroderma include elderly skin rashes and leathery skin Systemic sclerosis is an autoimmune disease. This means that the immune system causes damage to some of the body's own cells. Normally, our body makes proteins called antibodies to fight infections - for example, when we catch a cold or have a sore throat. These antibodies help to kill the germs causing the infection

Systemic sclerosis (SSc) is a systemic autoimmune disease that is characterised by endothelial dysfunction resulting in a small-vessel vasculopathy, fibroblast dysfunction with resultant excessive collagen production and fibrosis, and immunological abnormalities. The classification of SSc is subdivided based on the extent of skin involvement into diffuse cutaneous sclerosis (dcSSc), limited. Fibrosis is the hallmark of scleroderma, as well as a large and heterogeneous collection of human diseases. In these conditions, fibrosis represents the end result of a complex series of vascular and immune-mediated responses to chronic or recurrent injury in a genetically predisposed individual. Pathophysiology of Fibrosis in Systemic. Causes of scleroderma. The cause of scleroderma is still unknown, although medical professionals are continuing to carry out research into possible causes and some connections have been made. Professor Chris Denton gives a brief overview in the videos below. There is some evidence of a genetic link to systemic sclerosis, although most people. Scleroderma, also known as systemic sclerosis, is an autoimmune connective tissue disorder characterized by multisystem fibrosis and soft tissue calcification. As such, it affects many separate organ systems, which are discussed separately: musculoskeletal manifestations of scleroderma. pulmonary manifestations of scleroderma Scleroderma is an autoimmune condition that involves hardening of the skin and connective tissues, leading to either temporary or permanent cell damage. The disease may lead to improper functioning of any affected limbs, as well as the heart, lungs, or kidneys. Direct causes of the overactive immune response remain unknown

Pathogenesis of systemic sclerosis (scleroderma) - UpToDat

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by selective motor neuron degeneration and consequent progressive paralysis. Recent data have shown that microRNA-218 (miR-218) is enriched in motor neurons. However, whether neuronal miR-218 is modulated in ALS and plays a role in the disease is unknown. Now, Reichenstein et al. show that miR-218 controls. Scleroderma - Getting Diagnosed. Scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. These are the steps that you'd need to take. Dr John Pauling talks about why auto-antibodies are used for scleroderma diagnosis in the clip below

What causes scleroderma is still a mystery; sufferers of scleroderma will experience a buildup of collagen in the skin and other organs and this is what leads to the symptoms of the disease. Little is known about the causes of this condition although it is believed that excessive exposure to silica dust and polyvinylchloride may play a part in. amyotrophic lateral sclerosis (ALS), also called Lou Gehrig disease or motor neuron disease, degenerative neurological disorder that causes muscle atrophy and paralysis. The disease usually occurs after age 40; it affects men more often than women. ALS is frequently called Lou Gehrig disease in memory of the famous baseball player Lou Gehrig. Novel Insights Into Causes of Scleroderma Offer Potential New Treatment Strategies. In scleroderma, immune cells invade the skin, but the role this incursion plays in the disease is unclear. Now, scientists will be better able to address the immune system's role thanks to a new mouse model of scleroderma, which mirrors many aspects of the. Missing Chapter. this web site. In early 2009, the Disease Management Project was updated with new and revised chapters. There are now over 180 chapters available in 14 specialties. Browse the section index located on the left, or see the complete table of contents Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive and fatal disease, attacking neurons that control voluntary movement. These neurons die over time. The result is the gradual loss of muscle movement, speech, swallowing, and eventually, breathing

Scleroderma: Who gets and causes - AA

Systemic scleroderma causes sclerodactyly, which is an autoimmune disease and a rare form of arthritis that affects fewer than 500,000 people in the United States. Not everyone with scleroderma. 1. Introduction. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by death of pyramidal neurons in the motor cortex (upper motor neurons) and motor neurons in the brain stem and central spinal cord (lower motor neurons). This results in muscle weakness, progressive motor disability, and finally death. Multiple sclerosis (MS) is a chronic disease affecting the central nervous system (the brain and spinal cord).MS occurs when the immune system attacks nerve fibers and myelin sheathing (a fatty substance which surrounds/insulates healthy nerve fibers) in the brain and spinal cord. This attack causes inflammation, which destroys nerve cell.

Scleroderma - Basic Science - Orthobullets

Scleroderma - Wikipedi

Learn about symptoms, causes and treatment options in the multiple sclerosis condition guide available at U.S. News and World Report Multiple sclerosis is a disorder where your immune system is compromised and the protective coverings of nerve cells are being attacked. Learn how to detect the early signs and symptoms of MS. Scleroderma is a chronic degenerative disease that afflicts more than 300,000 Americans, primarily women. The life-threatening disorder is marked by dramatic tissue damage including hardening of. Multiple sclerosis is an autoimmune disease. That means your immune system mistakenly attacks healthy tissue, causing damaging inflammation. In the case of MS, immune cells target your central. Hippocampal sclerosis is now recognized as one of the main causes of focal epilepsy and is present in approximately 10% of adults with new-onset focal epilepsy 5). Moreover, hippocampal sclerosis often causes refractory epilepsy and is the sole pathology in about a third of all surgical resections for epilepsy and is an associated pathology so.

Scleredema: Background, Pathophysiology, Etiolog

Causes/Inheritance. About 5 to 10 percent of ALS is familial — meaning it arises in families in which there is a history of ALS. Several genes associated with ALS have been identified or at least mapped to a specific region of a chromosome. The other 90 to 95 percent of ALS is sporadic, meaning it occurs without a family history (in other. Scleroderma Causes: Abnormal Immune or Inflammatory Activity. Like many other rheumatic disorders, scleroderma is believed to be an autoimmune disease. An autoimmune disease is a disease that occurs when the immune system, for unknown reasons, turns against one's own body Other Causes: For sclerosis of the liver, frequent episodes of heart failure is a known trigger. What happens is, the bodily fluids pass to the liver during the coronary failure bout, causing liver damage. Other reasons for liver cirrhosis are parasitic infections and viral infections

Systemic Sclerosis (Scleroderma): Pictures, Symptoms, Cause

Multiple Sclerosis typically affects young adults between 20-40 years of age and has a higher prevalence in women. Life expectancy is shortened slightly in persons who suffer from MS, and the survival rate is linked to disability.Death usually results from secondary complications, such as pulmonary or renal causes Several reports have demonstrated associations between scleroderma and cancer and between multiple myeloma and autoimmune diseases. Few papers have also reported the concurrence of scleroderma and multiple myeloma. We report a case of multiple myeloma that developed in a male patient after 28 years of fulfilling a diagnosis of scleroderma. The main presenting feature of multiple myeloma was. Possible Causes of Multiple Sclerosis Researchers have studied a variety of possible causes for multiple sclerosis (MS), and a combination of factors appears to be involved. A popular theory looks at commonly known slow-acting viruses (one that could remain dormant for many years), such as measles, herpes, human T-cell lymphoma, and Epstein-Barr Multiple Sclerosis (Overview, Signs ,Symptoms, Types , Complication, Causes , Risk factors, Diagnosis, Home Remedies , Treatment and Prevention) What is multiple sclerosis? Multiple sclerosis is a medical condition that affects the brain and spinal cord and results in causing a wide range of disabilities in the affected people

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Multiple sclerosis is a chronic disorder of the central nervous system (CNS) that causes the destruction of the covering (myelin sheath) over the nerves. The course of this disease is variable; it may advance, relapse, remit, or stabilize. The demyelinating plaques or patches scattered throughout the central nervous system interfere with the. Causes of MS Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and damage to the myelin sheath in cells of the central nervous system, composed of the brain and spinal. sclerosis [sklĕ-ro´sis] an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration. adj., adj sclerot´ic. amyotrophic. In addition to Dry Mouth, here are other symptoms of Scleroderma (in no particular order of significance): Swelling of hands and feet. Hardening and thickening of skin. Joint pain and stiffness. Cold fingers or toes that turn red, white, or blue. Shiny, tight, less flexible skin. Red spots on face and chest Multiple sclerosis (MS) is a condition which can affect the brain and/or spinal cord, causing a wide range of potential symptoms, including problems with vision, arm or leg movement, sensation or balance. It's a lifelong condition that can sometimes cause serious disability, although it can occasionally be mild