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Depot injection for bipolar disorder

Depot Antipsychotics in the Prophylaxis of Bipolar

Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD) A review of studies into long-acting antipsychotic drugs for bipolar disorder has found that several trials have shown that depot antispsychotics are effective in reducing relapse in bipolar disorder and that further controlled trials are needed into their effectiveness Depo Antipsychotics 4 It is given by injection into a muscle. You need an injection every medication is also used to treat bipolar disorder. This medication helps control and reduce symptoms such as hallucinations, anxiety, agitation, social withdrawal, loss of appetite,. Currently, the only long-acting injectable antipsychotic that has been approved by the US Food and Drug Administration for the treatment of bipolar I disorder is risperidone (Risperdal, Janssen)... Personality disorder and depot injection | Mental Health Forum. Welcome! It's great to see you. If you'd like to talk with people who know what it's like. Our forum members are people, maybe like yourself, who experience mental health difficulties or who have had them at some point in their life. Forums

Paliperidone 9hydroxyrisperidone Molecule It Is Atypical

Long-acting injectable antipsychotics for the maintenance

  1. Invega Sustenna is an intramuscular injection given every month. It needs to be given by a healthcare professional. It's usually injected into the upper arm or buttocks. The first two doses are usually given one week apart
  2. Depacon solution is available in 5 mL single-dose vials for intravenous injection. Each mL contains valproate sodium equivalent to 100 mg valproic acid, edetate disodium 0.40 mg, and water for injection to volume. The pH is adjusted to 7.6 with sodium hydroxide and/or hydrochloric acid. The solution is clear and colorless
  3. A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics. The medication used in depot injections is the same as other forms of the drug, such as tablets or liquid
  4. Treatment of bipolar I disorder Acute treatment of adults with manic and mixed episodes as monotherapy and as adjunct to lithium or valproate Maintenance treatment of adults as monotherapy and as..
  5. Also known as: Invega, Invega Sustenna, Invega Trinza Paliperidone has an average rating of 5.3 out of 10 from a total of 40 ratings for the treatment of Bipolar Disorder. 43% of those users who reviewed Paliperidone reported a positive effect, while 43% reported a negative effect
  6. Olanzapine as pamoate monohydrate is a long-acting injectable or depot form of olanzapine. It is approved for maintenance treatment of schizophrenia in adults sufficiently stabilised during acute treatment with oral olanzapine. 2 It is given by deep intramuscular (IM) gluteal injection every 2 or every 4 weeks
  7. Li K, Liao YB, Yang Z, et al. Case report: paliperidone palmitate in the management of bipolar I disorder with non-compliance. Front Psychiatry. 2021;11:529672. 2: Buoli M, Ciappolino V, Altamura A. Paliperidone palmitate depot in the long-term treatment of psychotic bipolar disorder: A case series. 2015;38(5):209-2011

We searched PubMed and MEDLINE for publications on LAIs, depot antipsychotics and bipolar disorder using the search terms, bipolar disorder AND antipsychotic agents AND (depot OR long acting injectable OR LAI). To ensure inclusion of all available articles, reference lists of all relevant papers were checked To get a prescription for this medicine, you first need to use Invega Sustenna, which you take monthly, for at least 4 months. You don't inject long-acting drugs yourself. You need to go to a.. INDICATIONS. ABILIFY MAINTENA ® (aripiprazole) is a prescription medicine given by injection by a healthcare professional for: treatment of schizophrenia in adults. maintenance treatment of bipolar I disorder in adults. It is not known if ABILIFY MAINTENA is safe and effective in children under 18 years of age See guidance on Administration of oil-based Depot and Long-Acting IM Antipsychotic Injections. Aripiprazole. 400mg injection. Flupentixol decanoate. 20mg/ml, 40mg/2ml, 50mg/0.5ml, 100mg/1ml, 200mg/ml injection. Haloperidol decanoate. 50mg/ml, 100mg/ml injection. Baseline ECG is recommended Abilify Maintena side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. High doses or long-term use of aripiprazole can cause a serious movement disorder that may not be reversible

episode associated with Bipolar I Disorder requiring treatment within the last three years, treatment with lithium or valproate for Bipolar I Disorder for a minimum of two weeks prior to randomization, and a YMRS total score ≥20. • The study consisted of a 14-day screening and wash-out phase, followed by a 6-wee Depo-Provera (Medroxyprogesterone (Injection)) received an overall rating of 4 out of 10 stars from 908 reviews. See what others have said about Depo-Provera (Medroxyprogesterone (Injection)), including the effectiveness, ease of use and side effects In the UK, lithium is the main medicine used to treat bipolar disorder. Lithium is a long-term treatment for episodes of mania and depression. It's usually prescribed for at least 6 months. If you're prescribed lithium, stick to the prescribed dose and do not stop taking it suddenly unless told to by your doctor Antipsychotic medications are used as a short or long-term treatments for bipolar disorder to control psychotic symptoms such as hallucinations, delusions, or mania symptoms. These symptoms may. Bipolar Disorder Support Group. Bipolar disorder is not just a single disorder, but a category of mood disorders marked by periods of abnormally high energy and euphoria, often accompanied by bouts of clinical depression. This is the place to talk about your experience with bipolar disorder, learn from others' experiences, and find support

Depot antipsychotic prophylaxis in bipolar affective disorde

While 10 years ago there was concern that bipolar disorder was being under-diagnosed, there is now growing evidence that the pendulum has swung to the opposite direction of overdiagnosis, particularly for bipolar II disorder. 6 The first evidence for this came from two US centres in 2008, 7,8 which reported that a high proportion of patients presenting to clinical services with a diagnosis of. Comparison of Typical and Atypical Antipsychotic Depot Injections A 2010 study compared the effectiveness of LAR injection (n=122) and zuclopenthixol (n=31) and flupentixol (n=43) depot injections in patients with schizophrenia, schizoaffective disorder or delusional disorder through retrospective review of electronic patient records.11 The stud

Depot aripiprazole as maintenance treatment in bipolar

This column is partly a report on the marketing of Abilify, the atypical antipsychotic that has become America's best-selling drug. It's also an appeal for advice and feedback from the RxISK and Mad in America communities, and a call for some brainstorming about strategy. The plans laid out by drugmakers Otsuka and Lundbeck for Abilify's future, and the cooperation they're getting from. Abilify Maintena contains an atypical antipsychotic for intramuscular injection given once monthly. It is already approved to treat schizophrenia and Tourette's disorder in adult patients. Its.

Long-acting injectable antipsychotics (LAIs) for

  1. LAI first-generation antipsychotics (FGA) (depot neuroleptics) are not recommended in the early course of schizophrenia and must be avoided in bipolar disorder. 3. LAI antipsychotics have long been viewed as a treatment that could only be used for a small subgroup of patients with non-compliance, frequent relapses or who pose a risk to others
  2. Risperdal depot injection for bipolar disorder. I was almost chemicaly raped with this risperdal consta Injection against my will. This is happening to victims of psychiatry alot lately. This is a human rights violation not medical treatment. Psychiatry is like going to the worlds stupidist mechanic who never tests for ignition, compression.
  3. istered by either deep intramuscular deltoid or gluteal injection by a healthcare professional. After the first injection of ABILIFY MAINTENA, treatment with oral aripiprazole ( 10 mg to 20 mg) or current oral antipsychotic should be continued for 14 consecutive days. If there are adverse reactions with the 400 mg.
  4. Home › Forums › Psychiatric Drugs › Risperdal Consta Injection for Bipolar Disorder Tagged: Risperdal Consta Injection for Bipola. I was almost chemicaly raped with this Risperdal Depot Injection against my will. This is happening to victims of psychiatry alot lately. This is a human rights violation not medical treatment
  5. 1. Introduction. Bipolar Disorder (BD) is a severe, recurrent and disabling mood disorder characterised by manic, hypomanic or mixed episodes, and alternating episodes of depression that affects approximately 2% of worldwide population (Grande et al., 2016).Affective episodes are recurrent and commonly associated with unfavorable outcomes, including poorer cognitive performance and greater.
  6. Injectables work by slowly releasing the medication into your body. Some medications attach to fat cells and release drugs slowly. Other drugs have a carbohydrate chain that wraps around the drug - when the chain breaks down slowly, it releases the meds. Other medication use microsphere or nanocrystals that slowly dissolve and release the drug
  7. Objectives: The treatment of bipolar disorder (BD) cannot be limited to the remission of acute phases but includes the long-term treatment in order to prevent relapses, poor outcome, and chronicity. The purpose of this article is to present 3 cases of severe psychotic bipolar patients treated with monthly injection of paliperidone pamoate

Background: Non‐adherence is a significant problem in bipolar disorder. Second‐gen ‐ eration antipsychotics (SGA) long‐acting injections (LAIs) may improve adherence in bipolar disorder and may prevent relapses. However, the evidence is limited and conflicting. Objective: The objective of this study was to evaluate efficacy and safety. Depo-Medrone injection contains the active ingredient methylprednisolone, which is a type of medicine known as a corticosteroid. bipolar disorder or schizophrenia. Steroids can sometimes cause. Schizophrenia depot injection Bipolar disorder (adults and pediatric patients), acute monotherapy for mania Bipolar disorder (adults and pediatric patients), acute adjunctive treatment to lithium or valproate for mania Bipolar disorder (adults only), acute treatment of manic or mixed episode First FDA approved, once-monthly, long-acting injectable for the maintenance monotherapy treatment of bipolar I disorder in adults1,2New indication for ABILIFY MAINTENA is based on studies evaluating efficacy and safety in adult patients with bipolar I disorder1 (TOKYO, Japan & VALBY, Denmark, July 28, 2017) - Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S today announce Psychotherapy is a vital part of bipolar disorder treatment and can be provided in individual, family or group settings. Several types of therapy may be helpful. These include: Interpersonal and social rhythm therapy (IPSRT). IPSRT focuses on the stabilization of daily rhythms, such as sleeping, waking and mealtimes

Depo-Provera (DMPA), also known as the birth control shot, is a highly effective form of contraception that lasts for 3 months, and thus requires only 4 injections per year. DMPA contains a long-lasting form of depot medroxyprogesterone acetate that works as a contraceptive agent by preventing the ovaries from releasing an egg each month USES: Risperidone is used to treat certain mental/mood disorders (schizophrenia, bipolar disorder). This medication can help you to think clearly and take part in everyday life.Risperidone belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain Bipolar Disorder: Indicated as monotherapy for acute treatment of manic or mixed episodes associated with bipolar I disorder ; <10 years: Safety and efficacy not established ; 10-17 years: 2.5 SL q12hr initially; may increase to 5 mg SL q12hr after 3 days and to 10 mg SL q12hr after 3 additional days 2nd generation antipsychotic Invega, Inveg Tablets, injection and long-acting ('depot') injection Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. Symptoms of schizophrenia include hearing, seeing, or sensing things that are not real, having mistaken beliefs and feeling unusually suspicious Hill CL, Phadke D, Boyce KM. Four-week iloperidone depot injectable: safety and pharmacokinetic profile in patients with schizophrenia and schizoaffective disorder. Poster presented at: 161st annual meeting of the American Psychiatric Association; May 3-8 2008; Washington, DC. 5

Introduction. Bipolar disorder is a potentially lifelong and disabling condition characterized by episodes of mania or hypomania and episodes of depressed mood ( Grunze et al., 2013; Kendall et al., 2014).Bipolar disorder is associated with an excess mortality including an increased risk of suicide ( Grunze et al., 2013; Kendall et al., 2014).An estimated 25% to 50% of patients with bipolar. PHILADELPHIA - Long-acting, injectable formulations of antipsychotic drugs significantly boosted treatment compliance in patients with schizophrenia in a review of reimbursement records for more than 3,600 patients. The increased compliance achieved with depot administration of antipsychotic medications makes it an attractive alternative to. Some antipsychotics (particularly depot injections) have long half-lives and are unlikely to be associated with significant withdrawal symptoms (Table 1). depression and bipolar disorder. World Psychiatry 2015; 14:119-36. 10.1002/wps.20204 [PMC free article].

Mental Health Update: Depot treatments for bipolar disorde

Clopixol Depot injection is usually used to prevent further episodes of your illness. Clopixol belongs to a group of medicines called thioxanthene neuroleptics. It helps to correct chemical imbalances in the brain, which may cause mental illness. Your doctor, however, may prescribe it for another purpose Bipolar disorder Cannabis Club drugs It is important to know that the medication going into your body by a depot injection is exactly the same as the medication going into your body in tablet form. The only difference is the route through which its enters Oral Contraceptives Reduce Lamotrigine (Lamictal) Blood Levels. Lamotrigine (Lamictal) has been effectively used for the maintenance treatment of bipolar disorder. Many women suffering from bipolar disorder are of childbearing age; therefore an adequate contraception is a major concern that needs to be addressed in this population June, 2006), and an injectable formulation for schizophrenia and bipolar disorder (NDA 21-866, approved 20 Sept, 2006). The present NDA, submitted under section 505(b), seeks approval for Aripiprazole monohydrate extended-release suspension for injection [Intramuscular (IM) Depot] for the maintenance treatment of schizophrenia

OPAL- K Treatment Guidelines for Bipolar Disorder Page E4 . OPAL-K Medication Treatment Algorithm Page E5 . For Bipolar Mania/Hypomania . OPAL-K Medication Table for Bipolar Disorder Page E6-8 depot injection . Atypical Antipsychotic. Initial Dosing Children . 0.25 mg/day . Adolescents . 0.5m g/day . Maximum Dosing Children 3mg/day. My daughter got the depot injection in the hospital, supposed to last for 30 days. Calmed all symptoms of schizoprenia within days, no voices, no delusions, no paranoia. I thought it was a miracle. After 27 days the symptoms were returning, but she got another shot, and is symptom free. No side effects so far Depixol Injection 20 mg/ml is not intended for use in patients requiring doses of greater than 60 mg (3 ml) of flupentixol. Injection volumes of 2 - 3 ml should be distributed between two injection sites. More concentrated solutions of flupentixol decanoate (Depixol Conc Injection or Depixol Low Volume Injection) should be used if doses.

Olanzapine (Zyprexa): uses, dosage, side effects and brand

Depo Antipsychotics - Medication Informatio

  1. Schizophrenia and Bipolar Disorder KOL Interview - US, Southeast. This interview with a US-based key opinion leader (KOL) provides insights into prescribing habits, key marketed brands, long-acting injectables, late-phase pipeline therapies, and unmet needs for schizophrenia and bipolar disorder
  2. Hi, Risperidone long acting injections can be used in addition to conventional therapy for bipolar disorders in patients who are frequent relapsers. For these people who have had 4 or more relapses in the last 12 months, long acting injections of Risperidone maybe a useful adjunctive treatment. Talk to your treating doctor regarding the same
  3. Overview. Antimanic drugs are used to control acute attacks and to prevent recurrence of episodes of mania or hypomania. An antidepressant drug may also be required for the treatment of co-existing depression, but should be avoided in patients with rapid-cycling bipolar disorder, a recent history of hypomania, or with rapid mood fluctuations
  4. Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It is taken either by mouth or by injection into a muscle. The injectable version is long-acting and lasts for about two weeks. Common side effects include movement problems, sleepiness, dizziness, trouble seeing, constipation, and increased weight
  5. In the newly diagnosed cohort, the risk of psychiatric rehospitalisation was 32% lower during treatment with depot injections compared with treatment with equivalent oral formulations (HR, 0.68; 95% CI 0.53 to 0.86). Hence, use of depot antipsychotic medications results in the greatest benefit during the early phase of the illnes
  6. Antipsychotics are generally used to treat psychosis, but are also used to treat bipolar disorder. This page can help you find out more about antipsychotics, their side-effects and stopping you medication. Antipsychotic medication can come as tablets, a syrup or as an injection. The injections are called a depot. You may find a depot useful.

I explained my problems, and that I didn't want to be on depot injections anymore (as I am medication compliant 100%) and he raised my Seroquel to Seroquel XR 300mg in the morning, 300mg at night, and said if it made me drowsy, to take it all at night. antidepressant, antipsychotic depot, bipolar, bipolar disorder, depot injection. A current diagnosis of schizophrenia or bipolar I disorder, as defined by DSM-5 criteria. Body mass index of 18 to 35 kg/m2. On a stable dose of an atypical oral antipsychotic medication for at least 2 months prior to screening. Exclusion Criteria: Participants who have: Met DSM-5 criteria for substance use disorder within the past 180 days Bipolar Prophylaxis. Combinations of mood stabilisers or a mood stabiliser and an antipsychotic are often required. There is evidence that where combination treatments are effective in mania or depression then continuation with the same combination provides optimal prophylaxis. Patients should be offered continuation with medications that were.

Ive been on depot injections for 20years for schizophrenia and never told doctors it was drug induced ive had no symptoms for all those years although was admitted 6months ago and diagnosed with schizoeffective disorder which was also amphetamine misuse induced as this is the case ive took no My son has been diagnosed with Bipolar disorder. This open-label, single-arm, uncontrolled trial evaluated aripiprazole intramuscular (IM) depot as maintenance treatment for participants with bipolar I disorder. Enrolled participants included those who had completed Trial 31-08-250 (NCT01567527) as well as de novo participants who had not participated in Trial 31-08-250. Pre-assignment Detail Clopixol depot 200 mg Will start previously prescribed medicines again this time for 1 year complete. My mother has been diagnosed with Psychosis more than Bipolar disorder. She simply refuses to believe that she has Psychosis and doesn't take medications. This is also due to a prior experience with doctors A Cure for Bipolar Disorder Is Remission of Symptoms. Bipolar disorder is a life-long illness and no one in the medical community is suggesting bipolar can be cured (What to Do If You've Just Been Diagnosed as Bipolar). The best that can be hoped for is a suppression of symptoms through treatment Pain and discomfort at the injection site may result in patients' refusal of depot injections. The present study is a pilot study that attempts a systematic characterization of injection site pain. Method: Thirty-four consecutive outpatients suffering from DSM-IV-defined schizophrenia or schizoaffective disorder and treated with depot.

Once-Monthly Aripiprazole Effective in Bipolar Disorde

The long-acting or depot injection is an option when your symptoms have settled after taking tablets or liquid solution. Read more about depot antipsychotics . For more information about psychosis, antipsychotic medic ines and the common concerns about them, see Talking Minds, NZ Depot buprenorphine administered with subcutaneous (SC) injections led to improved treatment satisfaction compared with daily sublingual (SL) buprenorphine, according to a randomized clinical. While LAI antipsychotics have been an important option for managing schizophrenia for years, up until recently, the longest dosing interval was 4 weeks between injections. 1 Now, new injectable. Fluanxol depot injection presents as a clear, colourless to slightly yellowish oil. Fluanxol concentrated depot injection presents as a clear, yellowish to yellow oil. 4 Clinical Particulars. The possibility of a suicide attempt is inherent in schizophrenia and bipolar disorder, and close supervision of high risk patients should accompany. Paliperidone is a medication that works in the brain to treat schizophrenia and schizoaffective disorder. It is also known as a second-generation antipsychotic (SGA) or atypical antipsychotic. Paliperidone rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia/psychosis include

Antipsychotics | Health Navigator NZ

Personality disorder and depot injection Mental Health Foru

Anticonvulsants (antiepileptic) drugs are commonly used for people with bipolar disorder and are one of several classes of medications considered to be mood stabilizers (the mini pill), contraceptive progestin injections (such as Depo-Provera), contraceptive implant forms of progestin (such as Nexplanon), and progestin-containing IUDs,. Bipolar I disorder is a recurrent chronic mental illness. Abilify Maintena provides healthcare professionals (HCPs) a new treatment option for their patients who have established tolerability with oral aripiprazole, said Joseph Calabrese, MD, Director of the Mood Disorders Program at University Hospitals Cleveland Medical Center, and Professor of Psychiatry at Case Western Reserve. In this study, researchers compared the long-term effectiveness of psychiatric medications in preventing rehospitalization secondary to relapse of bipolar disease Bipolar disorder- epidemiology. Equal in both genders Onset typically- 25 Social economic- more affluent Depot meds. injection given every 2-4wks releases med slowly same effect as meds taken by mouth. Antipsychotic side effects. akinesia (muscular weakness).

Bipolar disorder (BD) is a chronic and cyclical mood disorder that is responsive to a number of evidence-based foundational medication treatments, Few studies included an objective measure of adherence aside from iTAB and the direct observation of receiving a depot injection [123, 124]. Another methodological issues was the absence of a. Consider offering depot /long-acting injectable antipsychotic medication to people with psychosis or schizophrenia: The prescribing is for bipolar disorder (NICE recommendation) and there is a history of poor period when the depot was prescribed and an indication of adherence with the depot injection. Paliperidone Long Acting Injection

Bipolar Disorders in Children and Adolescents

I explained my problems, and that I didn't want to be on depot injections anymore (as I am medication compliant 100%) and he raised my Seroquel to Seroquel XR 300mg in the morning, 300mg at night, and said if it made me drowsy, to take it all at night. atypical antipsychotic, bipolar, bipolar disorder, depot injection, invega, invega. Introduction Bipolar disorder requires long-term treatment but non-adherence is a common problem. Antipsychotic long-acting injections (LAIs) have been suggested to improve adherence but none are licensed in the UK for bipolar. However, the use of second-generation antipsychotics (SGA) LAIs in bipolar is not uncommon albeit there is a lack of systematic review in this area

(PDF) A typical antipsychotic: A reviewAnneliese StemWO2005041937A2 - Controlled release sterile injectable

Invega: Benefits, Side Effects, Dosage, and Interaction

Long-acting or 'depot' injections are used for maintenance once your symptoms have been eased by taking tablets. The injection slowly releases paliperidone into your body. You will need to receive the injection regularly, once every month. A three-monthly injection (Trevicta®) is available for people who are stable on once-monthly injections DESCRIPTION. Oral and parenteral atypical antipsychotic of the dopamine system stabilizers class Used orally in adults for schizophrenia, bipolar I disorder, and as an adjunct for major depression; short-acting injection used for agitation; distinct extended-release IM injections are used for maintenance of selected indications; used orally in pediatric patients for schizophrenia, bipolar I. Aripiprazole is a prescription medication that's used to treat schizophrenia, bipolar disorder, depression, autism, and Tourette syndrome. It's an antipsychotic drug. Aripiprazole is available as. Important Warning and Precaution Regarding Injection Site Reactions. In a short-term, clinical trial with ABILIFY MAINTENA in patients with schizophrenia treated with gluteal administered ABILIFY MAINTENA, the percent of patients reporting any injection site-related adverse reaction was 5.4%, and 0.6% for placebo Aripiprazole extended-release injection (Abilify Maintena) is also used for the ongoing treatment of people with bipolar I disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Aripiprazole is in a class of medications called atypical antipsychotics

Depacon (Valproate Sodium Injection): Uses, Dosage, Side

Bipolar disorder (BD), as defined by modern classification systems, encompasses episode of mania/hypomania and usually depression. Although acute episodes are significant, it is the recurrent nature of the illness that has implications for longer-term functioning and places it as the 4th leading cause of disability adjusted life years in people aged 10-24 (Gore et al. 2011) The DWP statement says: The following is a non-exhaustive list of examples of situations where a person with a mental condition (unaccompanied by a physical condition) could receive the mobility component of PIP at the enhanced rate: A person (person A) with a cognitive impairment who cannot, due to their impairment, work out where to go.

Studies of long-acting risperidone injection in bipolar disorder Switching from an oral antipsychotic As monotherapyAn open-label trial conducted during a 12-month follow-up period, studied the switch to depot risperidone in 10 patients in stable remission previously treated with low-dose oral second-generation antipsychotic monotherapy. 36 The. Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders and irritability associated with autism. It is taken by mouth or injection into a muscle. A Cochrane review found evidence of effectiveness. Bipolar I disorder is a chronic mental illness.6 People with bipolar I disorder experience one or more episodes of mania, and may have episodes of both mania and depression; however, an episode of depression is not necessary for a bipolar I disorder diagnosis.6 The lifetime prevalence estimate of bipolar I disorder in the U.S. is 1.0 percent. See NICE Bipolar disorder: assessment and management CG185. Antimanic drugs and mood stabilisers. Preparations. Comments. Asenapine . 5mg and 10mg tablets. NOT approved. Note: Different bioavailability of lithium preparations. Take care when changing from lithium carbonate tablets to lithium citrate liquid and vice versa ABILIFY MAINTENA is a depot preparation for intramuscular injection that administered monthly as a single injection. Otsuka Pharmaceutical discovered ABILFY MAINTENA, an atypical antipsychotic, which first received regulatory approval in 2013 in the U.S. and E.U. for the treatment of adult schizophrenia